Personal Info

E-mail: Francis.Szele(at)st-annes.ox.ac.uk; Francis.Szele(at)dpag.ox.ac.uk

Tel: 01865 282627

Web Link: http://www.dpag.ox.ac.uk/academic_staff/francis_szele/

Special responsibilities:
Junior Pro-Proctor (2008-09); Governing Body Representative to Association of Senior Members

Academic Background:
BS in Biology (the College of William and Mary, Virginia, 1985); PhD in Pharmacology (University of Pennsylvania, 1994); Postdoctoral fellow in developmental neurobiology (Harvard Medical School, 1994-99); Assistant Professor (Northwestern University Medical School, Chicago, 1999-2007); University Lecturer in Biomedical Science (Department of Physiology, Anatomy, and Genetics at Oxford University 2007-present); Tutorial Fellow in Developmental Neurobiology, St Anne’s College, 2007-present).

Teaching Interests:
Undergraduate: Neuroscience, developmental biology.

Graduate: Neuroscience, developmental biology.

Research Interests:
My lab studies adult brain stem cells, neurogenesis and migration. We use a large variety of appproaches including neurosphere cultures and 2-photon microscopy to examine cellular patterns and molecular mechanisms in the subventricular zone (SVZ). An overarching theme of our work is the intersection between brain development and repair.

Selected Publications:
G.E. Goings, D.A. Kozlowski, F.G. Szele, ‘Differential activation of microglia in neurogenic versus non-neurogenic regions of the forebrain’. Glia 54 (2006), 329-42
S.C. Nam, Y. Kim, D. Dryanovski, A. Walker, G. Goings, K. Woolfrey, S.S. Kang, C. Chu, A. Chenn, F. Erdelyi, G. Szabo, P. Hockberger, F.G. Szele, ‘Dynamic features of postnatal subventricular zone cell motility: A two-photon time-lapse study’, J Comp Neurol 505 (2007), 190-208
P.J. Ocbina, M.L. Dizon, L. Shin, F.G. Szele, ‘Doublecortin is necessary for the migration of adult subventricular zone cells from neurospheres’, Mol Cell Neurosci 33 (2006), 126-35
N.L. Sundholm-Peters, H.K. Yang, G.E. Goings, A.S. Walker, F.G. Szele, ‘Subventricular zone neuroblasts emigrate toward cortical lesions’, J Neuropathol Exp Neurol, 64 (2005), 1089-100