Personal Info

E-mail: Paresh.vyas(at)imm.ox.ac.uk
Tel: 01865 222489
Web Link: http://www.imm.ox.ac.uk/wimm-research/molhaem/paresh-vyas

Academic Background:

I was at Christ’s College, Cambridge, and Jesus College, Oxford, for my preclinical and clinical studies. My medical training was principally at a number of London teaching hospitals, where I eventually specialised in Haematology. I received a PhD in Molecular Medicine from Oxford and conducted my research in the laboratory of Professor Doug Higgs MRC Molecular Haematology Unit Weatherall Institute of Molecular Medicine. I spent three years at Harvard doing post-doctoral research in the laboratory of Professor Stuart Orkin researching into the mechanisms that control blood cell production.

Teaching Interests:

Undergraduate:
St Anne’s Medical student teaching

Graduate:
I help organise the Haematology teaching for the Pathology Course
I teach final year St Anne’s students
I mentor young doctors in training

Research Interests:

Molecular and cellular mechanisms that control normal blood cell production and understanding how these mechanisms are corrupted in Acute Leukaemia.

Selected Publications:

• O. Tunstall-Pedoe, A. Roy, A. Karadimitris, J. de la Fuente, N.M. Fisk, P. Bennett, P. Vyas and I. Roberts, ‘Perturbation of fetal hemopoiesis in Down syndrome: expansion of the MEP compartment precedes acquisition of GATA1 mutations’, Blood 112, 4507–11 (2008)
• I. Hamlett, J. Draper, J. Strouboulis, F. Iborra, C. Porcher and P. Vyas, ‘Characterisation of megakaryocyte GATA1-interacting proteins: the co-repressor ETO2 and GATA1 interact to regulate terminal megakaryocyte maturation’, Blood 112, 2738–49 (2008)
• B. Guyot, K. Murai, Y. Fujiwara, V. Garduno, N. Dear, S.H. Orkin, C. Porcher and P. Vyas, ‘Characterisation of a megakaryocyte-specific enhancer of the key haematopoietic transcription factor GATA1’, Journal of Biological Chemistry 281, 13733–42 (2006)
• C. Kuhl, A. Atzberger, B. Nieswandt, C. Porcher and P. Vyas, ‘GATA1-mediated megakaryocyte differentiation and growth control can be uncoupled and mapped to different domains in GATA1’, Molecular Cellular Biology 25, 8592–606 (2005)
• A. Sternberg, S. Killick, T. Littlewood, C. Hatton, A. Peniket, T. Seidl, S. Soneji, J. Leach, D. Bowen, C. Chapman, G. Standen, E. Massey, L. Robinson, B. Vadher, R. Kaczmarski, K. Clipsham, A. Carr and P. Vyas, ‘Evidence for reduced B-cell progenitors in early (low risk) myelodysplastic syndrome’, Blood 106, 2982–91 (2005)
• N.P. Rodrigues, R. Forkert, V. Janzen, D.M. Dombkowski, A.S. Boyd, S.H. Orkin, T. Enver, P. Vyas* and D.T. Scadden*, ‘Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem cell homeostasis’, Blood 106, 477–84 (2005). *Joint senior authors
• V. Valverde-Garduno, B. Guyot, E. Anguita, I. Hamlet, C. Porcher and P. Vyas, ‘Unexpected differences in the physical and functional organisation of the human and mouse GATA1 loci: implications for cis-element identification’, Blood 104, 3106–116 (2004)
• P. Vyas, K. Ault, C.W. Jackson, S.H. Orkin and R. Shivdasani, ‘Consequences of GATA-1 deficiency in megakaryocytes’, Blood 93, 2867–75 (1999)
• P. Vyas, F.A. Norris, J. Raji, P. Majerus, S.H. Orkin, ‘Inositol 4-Phosphatase type I regulates cell grow downstream of transcription factor GATA-1’, PNAS 97, 13969–701 (2000)
• P. Vyas, M.A. Mcdevitt, A.B. Cantor, S. Katz, Y. Fujiwara and S.H. Orkin, ‘Different sequences are required for expression in erythroid and magakaryocytic cells within a regulatory element upstream of the GATA-1 gene’, Development 126, 2799–811 (1999)
• P. Vyas, K. Ault, C.W. Jackson, S.H. Orkin and R. Shivdasani, ‘Consequences of GATA-1 deficiency in megakaryocytes’, Blood 93, 2867–75 (1999)
• P. Vyas, M.A. Vickers, D. Simmons, C.F. Craddock, H. Ayyub and D.R. Higgs, ‘Cis-acting sequences regulating expression of the human globin cluster lie within constitutively open chromatin’, Cell 69, 781–93 (1992)